Ƹ-ȭ ޵
å Ƿ ǰ ǻ ޵ Ÿ
ü
ǰ
޵ > ǰ
ǰ ȭ Ÿ̸ ϴ ο ߰ߴ
ȣ , ڷι̾ 籸
Ϻ Ʈ Ȯ Է : 2021-02-20 13:15:36
۸޵ ڣ

ȭ Ÿ̸ӷ Ҹ ڷι̾ ִ ο Ը ׾ , ȭ  ̷ο ȿ ִ ̷ õƴ.

20 б к ȣ ִ а ڴ ٱ⼼ ̿ ü ڷι̾ Ӱ 籸Ǵ ߰ߴ.

̹ ʷ Ϲ ݺ ƴ ٸ · ڷι̾ 籸 ʸ ߴ. ̸ ΰ ϼ Ǵٸ ڷι̾ ɼ 巯.

ڷι̾ ü ȣ Īϸ, п ߿ ȣ Ѵ. ڷι̾ ̰ Ϸ ª п ߴ ȭ · , ̷ ڷι̾ п Ÿ̸ӷε Ҹ.

Ϲ ü ڷι̾ ִ , Ȱ пϴ ٱ ڷθӷ ȿҸ ڷι̾ ̸ Ѵ.

ڷθӷ ڷι̾ κп ܹ ȣȭ ʴ Ư ⼭( TTAGGG) ݺ ٿ DNA Ҹ Ѵ. ϼ κ ڷθӷ ̿ ڷι̾ ̸ ϰ п ɷ .

ڷι̾ ̸ п ϸ鼭 ϴ ȭ ü ü ȭ ߿ϸ, ߸Ǹ ߻ ִ.

ڷθӷ ȿҸ Ȱ ʴ Ÿ̸Ӹ ϴ Ī ڷι̾ (Alternative Lengthening of Telomeres, ALT)̶ θ. ALT ̿ϴ , ڷι̾ 빰 Ϲ ݺ ޶ ɼ ִ.

߿ ڷθӷ Ȱ ϰ 쿡 ALT ̿ ڽ ڷι̾ Ÿ̸Ӹ Ѵ.

׷ ΰ ALT ̿ϴ ϼ ڷι̾ ڷθӷ ϴ TTAGGG ܼ ݺȴ. ΰ̳ 𵨿 TTAGGG ڷι̾ ٸ ̰ ־.

ʷ ڷι̾ TTAGGG ܼݺ ƴ ٸ 籸 .

ڷθӷ Ȱȭ ٱ ϴ ڷι̾ ª п ñⰡ µ, Ϻ ALT ȰȭǾ п ӵ ȸ ߴ.

̶ ALT ܼݺ ƴ Ư . ٱ ߰ߵ ο ALT ڷι̾ ̶ ǹ̿ mTALT (mouse template for ALT) ƴ.

ڷι̾ , ȭ, ALT Ȱ, ALT ȭ ð ϸϱ ֽ پ ͽ (ü, ü, ϼ ü, ܹü м) ȰϿ, б ִб ڴ ƴ.

ٽ ߰ HMGN1̶ ܹ ALT ڷι̾ ϰ . HMGN1 ALT ڷι̾ Ͽ ڷι̾ 3 ϰ ϰ ڷι̾κ RNA ǵ ߴ. ڷι̾ RNA ڽ ڷι̾ DNA ȣۿν RNA-DNA (R-loop) ϴµ, ڷι̾ ȣ ƴ.

̹ ü κ ȣ ִ ڷι̾ ݺ ڷθӷ ȿҶ ܼ ƴ Ըߴ١ ڷι̾ ȣ ִ پ Ȯ ϴµ ⿩ϰ ƴ١ .

м Ŀ´̼(Nature Communications) 2 17 ƴ.  
޵ (dlwogur93@mdtoday.co.kr)


<ǰ ̴ ѹα ǥ Ƿ, ǰ Ź ޵, >

fan
纸     ̽ Ʈ īī丮 ̹
̿޵
Ǫ,ڽƽ
ǽð
ȭǰġ
ǰ
䴺
 SK̿̾-ٹ齺-û, ڷγ19
޵コ
ϴܿ
޵
񽺾 | ޹ħ | ûҳ⺸ȣå | ̸ּ ܼ ź | ޹ | ŬŰ | ãƿô±
copyright