> ǰ
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ȭ Ÿ̸ ϴ ο ߰ߴ
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ȣ , ڷι̾ 籸
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۸ ڣ
ȭ Ÿ̸ӷ Ҹ ڷι̾ ִ ο Ը , ȭ ̷ο ȿ ִ ̷ õƴ.
20 б к ȣ ִ а ڴ ٱ⼼ ̿ ü ڷι̾ Ӱ 籸Ǵ ߰ߴ.
̹ ʷ Ϲ ݺ ƴ ٸ · ڷι̾ 籸 ʸ ߴ. ̸ ΰ ϼ Ǵٸ ڷι̾ ɼ 巯.
ڷι̾ ü ȣ Īϸ, п ߿ ȣ Ѵ. ڷι̾ ̰ Ϸ ª п ߴ ȭ · , ̷ ڷι̾ п Ÿ̸ӷε Ҹ.
Ϲ ü ڷι̾ ִ , Ȱ пϴ ٱ ڷθӷ ȿҸ ڷι̾ ̸ Ѵ.
ڷθӷ ڷι̾ κп ܹ ȣȭ ʴ Ư ⼭( TTAGGG) ݺ ٿ DNA Ҹ Ѵ. ϼ κ ڷθӷ ̿ ڷι̾ ̸ ϰ п ɷ .
ڷι̾ ̸ п ϸ鼭 ϴ ȭ ü ü ȭ ߿ϸ, ߸Ǹ ִ.
ڷθӷ ȿҸ Ȱ ʴ Ÿ̸Ӹ ϴ Ī ڷι̾ (Alternative Lengthening of Telomeres, ALT)̶ θ. ALT ̿ϴ , ڷι̾ 빰 Ϲ ݺ ɼ ִ.
߿ ڷθӷ Ȱ ϰ 쿡 ALT ̿ ڽ ڷι̾ Ÿ̸Ӹ Ѵ.
ΰ ALT ̿ϴ ϼ ڷι̾ ڷθӷ ϴ TTAGGG ܼ ݺȴ. ΰ̳ TTAGGG ڷι̾ ٸ ̰ ־.
ʷ ڷι̾ TTAGGG ܼݺ ƴ ٸ 籸 .
ڷθӷ Ȱȭ ٱ ϴ ڷι̾ ª п ñⰡ µ, Ϻ ALT ȰȭǾ п ӵ ȸ ߴ.
̶ ALT ܼݺ ƴ Ư . ٱ ߰ߵ ο ALT ڷι̾ ̶ ǹ̿ mTALT (mouse template for ALT) ƴ.
ڷι̾ , ȭ, ALT Ȱ, ALT ȭ ð ϸϱ ֽ پ ͽ (ü, ü, ϼ ü, ܹü м) ȰϿ, б ִб ڴ ƴ.
ٽ ߰ HMGN1̶ ܹ ALT ڷι̾ ϰ . HMGN1 ALT ڷι̾ Ͽ ڷι̾ 3 ϰ ϰ ڷι̾κ RNA ǵ ߴ. ڷι̾ RNA ڽ ڷι̾ DNA ȣۿν RNA-DNA (R-loop) ϴµ, ڷι̾ ȣ ƴ.
̹ ü κ ȣ ִ ڷι̾ ݺ ڷθӷ ȿҶ ܼ ƴ Ըߴ١ ڷι̾ ȣ ִ پ Ȯ ϴµ ϰ ƴ١ .
м Ŀ´̼(Nature Communications) 2 17 ƴ.
(dlwogur93@mdtoday.co.kr)
<ǰ ̴ ѹα ǥ Ƿ, ǰ Ź , >
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